multiple myeloma lab findings electrolytes

The purpose of the retrospective study was to assess the hematological profile, different biochemical parameters, and the serum electrophoresis patterns of patients consistent with clinical symptoms of multiple myeloma. It is the second most common adult hematological malignancy, and it is the most common cancer with skeletal components as its primary site. I have no idea if this problem applies to your situation, but I thought I would mention it, just in case.Objectives: Multiple myeloma (MM) is a malignant disorder characterized by proliferation of a single clone of plasma cells derived from β-cells in the bone marrow. Unlike Parkinson's disease, which also is dopamine related, my condition does not cause deterioration of the dopamine-producing cells in the brain.

Dopamine production increases during the day. I actually could get some sleep during the daylight hours, maybe an hour or two here and there. For me, it was a general agitation and muscular tension that increased as night-time approached, such that I was not able to relax my body enough to sleep. I never suffered from a feeling of restlessness in my legs, and perhaps that was why other doctors could not diagnose it. I should add that the name 'restless leg syndrome', is a misnomer, at least in my case. A very small dose, taken in the late evening, of a dopamine agonist (as opposed to an 'antagonist'), pramipexole (Mirapex), completely and instantly solved the problem. It is caused by too great a drop in dopamine as night-time approaches. By accident, I found an excellent sleep doctor who diagnosed it immediately: restless leg syndrome, also known as Willis-Ekbom disease. Finally I was even sent to a psychiatrist and then to a psychologist, and they came up with unhelpful psychological interpretations. I had terrible sleep problems that no doctor could figure out. I am hoping somebody here can weigh in with something with potential solutions, or even thoughts such as you shared! It will be interesting to get his take on that. We do have an appointment with the 'head honcho' sleep doctor in town next week. He averages waking 5 times in a 5-8-hour usage period. I was finally able to access his records from his bipap machine. One of those was specifically done on myeloma patients. Two studies I read correlated sleep difficulties in cancer patients to fatigue levels. He does still have active myeloma as far as we know his M-spike is 0.6 g/dL. When it began, he was on far more drugs, but he's left them behind. His oncologist doesn't think it's medication-related either, since he's on almost no medications and only has Darzalex once a month. That resulted in several prescriptions that didn't work and the referral to the sleep doctor. Vmeyer Name: vmeyer Who do you know with myeloma?: my husband When were you/they diagnosed?: March 2016 Age at diagnosis: 65 Does anyone have any more information or experience with this, including what can be done about it?

I have read in some research that this is common with cancer, but they didn't offer any solutions. We hoped getting off pain medications would help, but it didn't. Everything works once or twice, then quits. We have tried various herbs, Benadryl (diphenhydramine), magnesium, melatonin, prescription sleeping pills, muscle relaxants (theory: leg cramps), Neurontin (gabapentin) (theory: restless leg), and antidepressants that I can think of. He is not taking dex except a little monthly with his infusion, so I don't think that is a factor. It did solve the apnea incidents, but he still wakes up about every 1-3 hours all night.Įven though Darzalex is keeping the myeloma somewhat controlled, he has some fatigue anyway, but getting up all the time at night is wearing him out (me, too, to some extent). We thought the bipap machine would solve everything, but it hasn't. He saw a sleep doctor, went through a couple of sleep studies, and was diagnosed with severe obstructive and central apnea, with 68 incidents per hour. My husband has ongoing difficulty staying asleep at night.

Multiple myeloma lab findings electrolytes